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Wham is designed for paired-end Illumina libraries with conventional insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, break up read through mapping, smooth-clipping, option alignment and consensus sequence based mostly proof to forecast SV breakpoints with solitary-nucleotide precision. Wham generates a combined pileup (catalog
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Wham clusters many of the candidate breakpoints and rounds their positions to the nearest tenth base pair. The place with the best read guidance is documented. When the delicate-clipped consensus sequence may be aligned to your putative breakpoint region using the Smith-Waterman algorithm, the breakpoint is further more refined to The placement on
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